The toxic properties of petroleum spirit (40°-60°C) and water-soluble absolute alcoholic extracts of the bark of Barringtonia acutangula (Gaertn.) were investigated on laboratory animals. The petroleum spirit extract when administered intra-peritoneally was found toxic to the experimental mice. The 24-hr LDW value was found 81.47 mg.kg’ 1 body weight. The  χ² value for the lethal dose was found significant at 0.1% level of significance. The petroleum spirit and water-soluble absolute alcoholic extracts when administered orally to rats showed some toxic properties but no mortality. The study reveals that the petroleum spirit (40°-60°C) extract of the bark of Barringtonia acutangula (Gaertn.) has a great prospect to decrease or substitute the use of synthetic pesticides, especially the organophosphates.